Uses of hydrocortisone cream and benadryl cream overlap, so it might be a case of which works better for you. Hydrocortisone is used without a prescription for the temporary relief of (1) minor. Trying to control it with Hydrocortisone 1% (ineffective), triaminaclone (effective for 10-30 seconds), daily doses of Zyrtec 10mg + Benadryl 25-50mg (effective but makes me too sleepy - at least I get some good rest and the hives are totally resolved when I wake). Hydrocortisone Vs Benadryl For Bed Bug/Mosquito Bites Many people mention hydrocortisone but that is a steroid and it causes thinning of the skin. Its ingredient is Hydrocortisone 1%. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap. Anusol Hc (Hydrocortisone) is a good topical steroid to try for treating minor rashes or skin irritation. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Connolly on benadryl cream vs hydrocortisone cream: This is a steroid cream and may actually worsen acne. It is used to treat inflammation, such as a skin allergy or eczema. I got the rash the first time three days (yes just 3 days) into treatment, probably covered probably 70-80% of my body, including my scalp. The only place it.I used eucerin calming cream or gold bond medicated lotion. Benadryl: La diphenhydramine appartient au groupe de médicaments appelés antihistaminiques. Les antihistaminiques s'utilisent pour traiter les symptômes causés par les allergies notamment une irritation oculaire et un larmoiement, des éternuements, un écoulement nasal, des éruptions et irritations cutanées. I also had a Hydrocortisone 2.5% prescription cream in my cabinet and it did not work. Was told to try benadryl cream that did not work. Finally used my poison ivy lotion called Clobex. For more information about Extra Strength Benadryl Itch Stopping Cream, visit or call 1-800-524-2624. For more information about Aveeno Active Naturals 1% Hydrocortisone Anti-Itch Cream, visit or call 1-800-428-3366.